granulocyte and monocyte purity

From: Maciej Simm (simmmmer@yahoo.com)
Date: Thu Jul 08 1999 - 17:21:50 EST


Hello again, 

My problem this week: 
1. how does one define a representative region to study
   monocytes and granulocytes?
2. how does one calculate the purity of such a region?

what we've been doing so far, is the same thing we do for lymphs, namely, 
define R1 on the ssc/fsc and using it "highlight" corresponding populations
on the CD45/14 plot, then draw R2 on the CD45/14 plot and use it as a gate
for a third plot plot (CD45/14) on which the LR quadrant is our purity. 

This doesn't quite work for monos/grans. The ssc/fsc plot resolves the two
populations quiet well, but CD45/14 has an overlap between the two. I wonder
if anyone here has worked with these populations and would like to contribute
their thoughts? Specifically, we are setting this template up for a BPD and 
sepsis study where we look at 18/11b, 18/62L, and 15/11b. 

thanks for any input!

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