Hello, I hope that I may be forgiven for asking a question that is not strictly flow, but I thought some of the clinical immunologists might be able to help with this question. We have followed a case of canine lymphoma that was a non-antibody producing B cell lymphoma at presentation. The dog was treated and went into clinical remission. He re-presented with an abdominal mass that consisted of IgA producing plasma cells (the dog had a monoclonal gammopathy). Sequencing of CDR3 of the initial lymphoma and the subsequent plasma cell tumor demonstrated that they were from the same clone. The original tumor expressed CD21 but not the plasma cell tumor that occurred later (unfortunately we have limited phenotyping ability in this species, so this was the only useful antibody). We have only recently developed the ability to type canine lymphomas by sequencing their antigen-combining region, and so we have little experience following lymphomas in dogs through chemotherapy. I have two questions: 1) Is it common for non-hodgkins lymphomas in people to exhibit the same type of differentiation (i.e. this tumor appears to have become more differentiated after chemotherapy)? 2) If this were a human patient how would you expect the immunophenotype of the two tumors to differ? Thanks in advance for your help. Anne Avery ==================================== Anne Avery, VMD, PHD Department of Pathology Colorado State Univ Ft. Collins, CO 80523-1671, USA voice:(970)491-1170 fax:(970)491-0603 aavery@cvmbs.colostate.edu ====================================
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