Re: DNA analysis softwares

From: Adam Treister (adam@treestar.com)
Date: Thu Jun 10 1999 - 22:43:01 EST


----->>> On 10-Jun-1999, Ng Bee Ling wrote:
>   I am looking for a software so as to determine the  % of cell cycle
>   phases (with gating properties) from listmode files. Is there such
>   software that could run both for files collectd from EXPO and
>   Cellquest?
--------------

FlowJo in an offline analysis package that will read both EXPO (PC) and
CellQuest (Mac) files.   You can compute the percentages in each of the
phases (as well as under-G1 and over-G2) for any gated population.

We currently have a limitation in the ability to export all of the cell
cycle statistics for all of the samples to a spreadsheet in a single step,
but that is implemented in the next release.

More info at:
http://www.treestar.com/flowjo/html/cellcycle.html

I get a lot of requests for the references to the models, so let me give
them here:

1) Watson Pragmatic
Cytometry 8:1-8 (1987)
Watson, Chambers, & Smith:  A Pragmatic Approach to the Analysis of DNA
Histograms with a Definable G1 Peak

2) Dean Jett Fox
Cytometry 1:71-80 (1980)
Fox:  A Model for the Computer Analysis of Synchronous DNA Distributions
Obtained by Flow Cytometry

3) Two Populations
Uses Dean-Jett model (with Fox modification) for both populations.

Adam

-----------------------------
Adam Treister
adam@treestar.com
http://www.treestar.com/flowjo
800-366-6045
-----------------------------



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