Dear flow-ers, Is there anybody here, who knows anything about the effect of S-nitrosoglutathion (GSNO) on P-selectin expression on human platelet in platelet-rhich plasma ? I see, that GSNO is a potent antiplatelet compound. Its IC50 value is 50 nM for thrombin-induced platelet aggregation. Why I measure only 20 % inhibition of P-selectin expression with 10 microM GSNO if platelets were activated with 10 microM TRAP-5 If you have suggestion, please ansewer ! Many thanks A. Boros
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