RE: Apoptosis

From: Tom Mc Closkey (thomasm@nshs.edu)
Date: Fri Feb 19 1999 - 14:59:04 EST


--- On Wed, 17 Feb 1999 15:28:35 -0500 (EST)  Richard Meister 
<meister.1@osu.edu> wrote:

>1.  What is the best positive control to use; i.e., an easy-to-grow cell
>line that can be reliably and predictably induced into apoptosis? 

	Jurkat cells treated with anti Fas Ab are useful as a positive 
control.  Details on culture conditions and kinetics of cell daeath can be 
found in AIDS Res Hum Retro, 14: 1413-1422, 1998.


>2.  How should one pronounce "apoptosis"?  When I first heard the term
>(probably 10 years ago), the second "p" was silent (A-pO-tO-sis).  Since
>then, I have increasingly heard the second "p" pronounced (A-pop-tO-sis).
>And, I can't find the word in a dictionary.

	" T o show the derivation clearly, we propose that the stress should 
be on the penultimate syllable, the second half of the word being pronounced 
like ptosis (with the p silent), ..."

from Kerr, Wyllie, and Currie, Apoptosis:  a basic biological phenomenon 
with wide ranging implications in tissue kinetics, Br J Cancer, 26: 239-257, 
1972.


Regards,
Tom


--------------------------------------------------------
Thomas W. Mc Closkey, Ph. D.
Director, Flow Cytometry
North Shore University Hospital
Biomedical Research Center
350 Community Drive
Manhasset, Long Island, New York 11030
ph: 516-562-4844 [office]; 516-562-1135/4641 [lab]
fax:  516-562-2866
2/19/99   12:10:22 PM
E-mail: thomasm@nshs.edu 
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