Hi Doug, Although the majority of recent studies using MHC tetramers have utilized MHC class I-peptide complexes, the first MHC tetramers generated (by Mark Davis many years ago) were of MHC class II molecules. A more recent paper from Marrack and Kappler's group describes the production and use of several MHC class II - peptide tetramers: Immunity (1998) 8:675. AW Andrew D. Wells, Ph.D. University of Pennsylvania Department of Medicine 904 Stellar-Chance Laboratories 422 Curie Boulevard Philadelphia, PA 19104 (215) 898-1951 (215) 573-2880 (FAX) adwells@mail.med.upenn.edu
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