CD71 up-regulation

From: linda.weaver@pharma.novartis.com
Date: Tue Jan 13 1998 - 09:35:45 EST

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    Greetings!

    CD 71, human transferrin receptor, is up-regulated on activated
    lymphocytes (as many are already aware).  Has anyone attempted to
    estimate quantitatively (by flow) how many receptors are expressed on
    activated cells?

    Also, to what extent do these anti-CD71 monoclonals on the market
    cross-react with receptors of non-human creatures?

    Thanks!

    Linda Weaver
    Genetic Therapy, Inc.
    Gaithersburg, MD 20877

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