While it is true that CD43 is not lineage specific, I would disagree
that it is of limited diagnostic utility in all types of cases. As
with any antigen, you have to know the limitations of its detection
and CD43 is expressed by almost all types of acute leukemia as well as
T cell lymphomas and some B cell neoplasms. The coexpression of CD43
with CD20, however, can be quite helpful in the B-cell lymphocytic
lymphomas, and CD43 is included in the immunophenotype descriptions of
the REAL classification. I believe that CD43 is as useful, or more
useful, than many antigens commonly studied by flow cytometry for
these B cell neoplasms (such as CD11c). By convention, however, it
has never made its way into most flow cytometry panels for these
diseases.
Dan Arber
______________________________ Reply Separator _________________________________
Subject: Re: CD43
Author: Howard Ratech <ratech@aecom.yu.edu> at INTERNET
Date: 12/18/97 10:34 AM
CD43 is not lineage specific and therefore has limited diagnostic utility.
The following reference may be of interest to you:
The "CD43 only" phenotype. An aberrant, nonspecific immunophenotype
requiring comprehensive analysis for lineage resolution. Segal GH et al.
Am J Clin Pathol 97:861-865, 1992
Sincerely,
Howard Ratech, MD
On Wed, 17 Dec 1997, Adrian O Vladutiu wrote:
>
> While antibody to CD43 are being commonly used in immunohistochemistry,
> for flow cytometry the use of this antibody is not listed in the many
> consensus reports on antibodies to be used for analysis of lymphoma by
> flow cytometry. Are there explanations for this?
>
>
>
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