RE: apoptosis?

From: Tom Mc Closkey (thomasm@nshs.edu)
Date: Tue Dec 16 1997 - 16:09:36 EST


--- On Mon, 15 Dec 1997 17:25:00 +0000  Andreas Simm 
<simm@wbzx06.biozentrum.uni-wuerzburg.de> wrote:

>In the literature, everything is possible:
>Apoptosis is dependent or independent
>on mitochondria, is stimulated or blocked
>by the same signal transduction pathway
>and so on.

	I think that what makes the apoptosis literature sometimes appear 
contradictory is that this is a very tightly regulated process which can be 
influenced by many variables: state of activation/maturation of the cell, 
cell types present, intracellular levels of pro- or anti-apoptotic 
molecules, cytokines, etc.  Thus, slightly different conditions can yield 
different results.

Tom


--------------------------------------------------------
Thomas W. Mc Closkey, Ph. D.
Director, Flow Cytometry
North Shore University Hospital
Biomedical Research Center
350 Community Drive
Manhasset, Long Island, New York 11030
ph: 516-562-4844 [office]; 516-562-1135/4641 [lab]
12/16/97   1:43:00 PM
E-mail: thomasm@nshs.edu 
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