I have a question about apoptosis. I get almost into trouble following the discussions about apoptosis. I'm not really familiar with apoptosis, but I have learned that apoptosis is one form of a programed cell death, which is characterised by DNA fragmentation. Now, nearly every form of cell death seems to be apoptosis, independent of DNA fragmentation. How is this form of cell death now characterised? In the literature, everything is possible: Apoptosis is dependent or independent on mitochondria, is stimulated or blocked by the same signal transduction pathway and so on. For me, this kind of research looks like the research on specific kinases as for example the PKC. The results were also very confusing (Ca dependent or not..) until it was clear, that a kinase family exists. Is it possible, that the same is true for the programed cell death. Apoptosis is one member of this family but there are maybe other members of this family. Can anybody help me with this problem? Thanks Andreas ------------------------------------------ Andreas Simm Physiologische Chemie II Biozentrum, Am Hubland D-97074 Wuerzburg FAX: +49-931-888-4113 Tel: +49-931-888-4128 E-Mail: Simm@biozentrum.uni-wuerzburg.de ----------------------------------------
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