Mike,
It would be really interesting if the thyroid hormone
was stimulating proliferation to the point of
swamping normal thymic selection to permit
double positive escape from the thymus. If so
you might predict an increased incidence of
autoimmune disease in such patients...just
a thought. It would be interesting to determine how
long-lived these cells are in the periphery.
Gene Pizzo/UCONN Health
----------
From: mkoratich@NATICK-CCMAIL.ARMY.MIL
To: cyto-inbox
Subject: CD4 8 coexpression again
Date: Friday, December 05, 1997 8:49AM
I'd like to thank all those that have responded to my question. I
have alittle more info for you.
The subject is a human female in her 30s. She is one of our labtechs
that we draw when we are playing with new assays. She is in excellent
health with the exception of being hypothyroid and on synthetic
thyroid hormone. I did CD3/4/8 staining on her and 2 others at the
same time. The other 2 where completely normal. She had no normal
CD8+ 4- cells. All the CD8+ cells were CD4+. Her CD4+/8- cells
looked fine. They had no CD8 expression. The FS/SS profile of the
CD8/4 double positives looked normal, and were evenly distributed just
like the CD4 cells. The CD45/14 was also good. I am going to run her
again next week and include Coulter count. Any further advice very
welcome.
Thanks,
Mike Koratich
USARIEM
mkoratich@natick-ccmail.army.mil
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