We had a similar case, but after doing a literature source, elected
to
call it a Hairy Cell Variant. When I discussed this with the
clinician, he indicated that they treated cases like that as HCL.
(He
also said they tend to go with the peripheral morphology as a
bottom
line for diagnosis.) (???) Unfortunately, although the patient's
immediate response to therapy was good, it was not long lasting.
The
particular patient I was testing at that time reacted similarly. I
have re-flowed him each reoccurance, and the CD103 positivity and
CD25
negativity remain constant.
Kathy Altig
Providence Portland Med,Ctr.
Portland,OR
______________________________ Reply Separator
_________________________________
Subject: Author: ,stetler@box-s.nih.gov [SMTP:stetler@box-s.nih.gov] at
PHSOR
Date: 10/10/97 9:09 AM
I have a case that immunophenotypically looks like hairy cell
leukemia (monoclonal kappa, CD20 bright, CD22 bright, CD103+, CD11c+,
CD19+, FMC7 bright and negative for CD10, CD5,and CD23, however the CD25
is
negative). The peripheral blood smear looks like hairy cell. The
clinician
from another institute reports the bone marrow, which I haven't seen,
doesn't look like hairy cell and the patient is not low in platelets.
She
thinks it may be splenic marginal zone lymphoma. Has any one seen CD103+
on
a real splenic marginal zone lymphoma?
Maryalice
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH
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