Hi CD8 cells that are CD45RA and CD62L are considered naive. Most (in normal people) CD8 cells that express CD62L also express CD45RA but some are CD45RA negative and are considered memory cells. I use the term negative loosely as the "negative" cells also express some CD45RA. Using CD62L alone as a naive marker in HIV infected individuals could give grossly inaccurate results. Have a nice weekend Simon Monard Aaron Diamond Center NYC
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