In the NIH experience, the only survivor had a bone marrow transplant. It
is a really bad disease with a fairly rapid demise.
Maryalice
>From: Witzig, Thomas E., M.D. Subject: RE: Hepatic Splentic gamma-Delta T-cell
>Lymphoma
>
>I have had some experience with this entity and we are writing up the Mayo
>cases seen so far. Unfortunately, its an aggressive disease. There are no
>known protocols - its really too rare for a protocol. I'd recommend: 1. An
>adriamycin containing regimen such as CHOP, CDE infusional (actually ECOG does
>have this open as a protocol and the patient could probably enter it --its for
>aggressive NHL not specifically gamma-delta), ProMACECytaBOM
>
>2. If responsive, I'd check the blood and marrow and transplant if clean. 3.
>If not a transplant candidate and does not get a CR with regimen in #1 then
>I'd try a platinum regimen OR 2-deoxycoformycin- Pentostatin (good for T-cell
>processes and commercially available and usually outpatient and
>well-tolerated.
>
>
>Sincerely,
>
>Tom Witzig (witzig.thomas@mayo.edu)
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH
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