Dear collective wisdom of clinical cytometry- I recently had to interprete a lymphocyte transformation/activation assay on a 22 year female with history of repeated pulmonary infections. All the usual lymphocyte subset, immunoglobulin and complement assays were normal. However our assay for PHA and ConA (not PWM) induced CD69 expression for T cells (not B cells) was below our normal range, yet the proliferative response to the same antigens, as measured by BRDU incorporation and %S phase, was normal. I have not seen this before, nor able to find anything on a literature search. Has anyone had or know of a similiar experience? Bruce H. Davis Wm. Beaumont Hospital
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