RE: Proliferation index and apoptosis

From: Tom Mc Closkey (thomasm@nshs.edu)
Date: Wed Apr 23 1997 - 13:30:34 EST


--- On Tue, 22 Apr 1997 08:54:03 -0600  Anna Travelstead 
<travelst@wpsmtp.siumed.edu> wrote:
  The PI wants
>DNA cell cycle analysis, proliferation index and apoptosis index
>performed.  Does anyone have recommendations on the best apoptosis
>kit for use on a FACS Vantage? 

The easiest way to measure these 3 parameters is to stain for DNA content 
which allows you to quantitate apoptosis [below diploid] and proliferation 
[above diploid] simultaneously.  If you wish to analyze cell death using a 
different method you have many choices, including TUNEL, annexin, which are 
in kit form.  There are also many other methods discussed in current 
literature.

Good luck,
Tom

--------------------------------------------------------
Thomas W. Mc Closkey, Ph. D.
Director, Flow Cytometry
North Shore University Hospital
Biomedical Research Center
350 Community Drive
Manhasset, Long Island, New York 11030
ph: 516-562-4844 [office]; 516-562-1135/4641 [lab]
4/23/97   11:37:08 AM
E-mail: thomasm@nshs.edu 
--------------------------------------------------------



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