Re: apoptosis

From: LAADAMS@am.pnu.com
Date: Tue Apr 22 1997 - 14:08:22 EST


Jane,

Contact the good people at Phoenix Flow Systems.  They sell this as a kit 
which includes positive and negative controls.  They can be reached at 
800-886-3569 or email: info@phnxflow.com.

Lisa Adams
Cancer Research
Pharmacia & Upjohn
Kalamazoo, MI


______________________________ Reply Separator _________________________________
Subject: apoptosis
Author:  "Hughes; EJ; Jane; Ms" <JHUGHES@ICH.UCT.AC.ZA> at INTERNET
Date:    4/22/97 11:30 AM


Dear Flowers

We are setting up an apoptosis assay using FITC anti BrdU ( the 
method of Xun Li, Traganos and Darzynkiewicz) and I have a few 
questions (I do hope not TOO basic!!)

1. Should one use an Isotypic control.
2.I want to immunophenotype first, should I lyse the RBC after 
immunophenotyping and before DNA cleavage. (I wasn't sure from the 
method whether Triton would lyse the cells as RBC lysis is not given 
as a step)
3. What are the options for positive controls.

Thanks

Jane Hughes
Immunology Section
ICH Lab, Dept Paediatrics
Red Cross Children's Hospital
Rondebosch, Cape Town, South Africa



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