Dear colleagues, In amplifying on Spizek's and Paul's concern, I want to contribute a few thoughts and proposals. As a person who has conscientiously seen the end of world war II and personally experienced the difficulties of the postwar period, I believe, the temporary assistance to Eastern European scientists, constitutes a high moral duty to us. It seems fundamentally important to help those who in spite of unpaid salaries, non entertained buildings and outdated instrumentation remain attached in thinking and action to their scientific disciplines. Outstanding scientists are working in or have come from these countries and during better times, these regions have actively contributed over long periods to the extension of worldwide scientific knowledge. Our intended effort should therefore aim to maintain and extend the intellectual attachment of Eastern European scientists to the current developments in our discipline during the present economic depression in these countries. While it is certainly neither within the capacity of individual scientists nor of scientific organisations like ISAC or national cytometric societes to replace missing research budgets, the maintenance of the intellectual attachement by electronic networking seems a comparatively feasable and centrally appropriate task for us scientists as genuine carriers of the present intellectual and experimental knowledge. Before elaborating an action plan, such a program should be clearly identifyable by a forward directing name. Temporary Assistance Program East (TAPE) or Paul's more general Scientist Assistance Program (SAP) seem reasonable approximations to our intentions. The following actions seem profitable to Eastern European scientists and feasable by us: 1. to *distribute* the Purdue CD with its original or slightly modified content. The CD could additionally contain the table of contents and the abstracts of Cytometry and CCC (by kind permission of J.Wiley) and ACP (IOS-Press) in addition to the generously offered but nevertheless more cost limited numbers of copies of both journals provided free of charge by either Wiley/Liss or by ISAC/CCS. 2. to *collect* E-mail addresses of Eastern European scientists and of cytometry organisations or local interest groups e.g. around larger cities in these countries. 3. to *install* E-mail servers in adjacent countries profiting from the fast access lines i.e. in Germany and Austria. These mail servers could be operated in English but more realistically in the respective native languages or in a split mode. Their Internet transcripts could be displayed or mirrorred on the CytoRelay or Purdue Internet nodes. This would permit the intercommunication of locally distant research groups and may facilitate the foundation (see e.g. EFCS discussion experience at: http://www.biochem.mpg.de/valet/efcs.html) of cytometric organisations in Eastern Europe. Such interest groups may be in many cases more efficiently addressable e.g. for the organisation of courses, access to and redistribution of information (e.g. CD's), generation of specific documentation in the respective native languages etc. than individual scientists. While the provision and maintenance of mail servers is comparatively easily feasible e.g. via the Max-Planck-Gesellschaft in my personal case, the production of *Internet transcripts* of the E-mail messages and their linking into the Internet *requires work* despite the existence of particular software (e.g. at Purdue). Considering, however, the *Off-line Internet* concept, explained in: http://www.biochem.mpg.de/valet/offint1.html, agreed scientists in Eastern European countries can prepare the transcripts of the radiated E-mail messages themselves, zip and e-mail them to Paul or to me for a direct link into the *CytoRelay* or *Purdue* nodes. One would in other words follow the same procedure, presently used for the maintenance of the mutual CytoRelay/Purdue www-mirrors. Once on the Internet, the information could be *incorporated* into the regularly updated Purdue CD or onto a special East European CD. A special CD may also be of interest to commerical companies for specific product advertisement i.e. the production and distribution of the CDs could be covered by industrial sponsors. Native language pages should create a particular impact e.g. on US, Europe or elsewhere located emigrant/immigrant scientists of these countries who will intuitively develop a better feeling for the needs of their compatriotes. 4. to *collaborate* on the substantial problems of multiparameter data analysis in conjunction with the intelligent computer interpretation of such results. Many of us are aware of the traditionally very highly developed mathematical disciplines in the Eastern European countries. Pairing the existing experimental knowledge with their mathematical modelling expertise may well generate entirely new concepts for multiparameter data processing and interpretation. The inherent advantage of this is that one needs intellectual concepts, experimental data and electronically linked PCs but not necessarily high research budgets. I am personally trying to organize an electronic collaboration with Prof.Zemskov and Dr.Vasilyev of the National Immunology Institut in Moscow. A particular stimulator towards such work could be a supplement in Cytometry on "Current Concepts of Multiparameter Data Analysis in Cytometry" with the inclusion of contributions from Eastern European Countries. This would define the state of the art and emphasizes our concern for the joint development of more efficient strategies of data analysis. Jan Visser and Brian Mayall as Cytometry Editors are challenged at this point. 5. to *organize* cytometry related courses. The already existing practical experience is that such activities are highly welcome to scientists in Eastern countries. The lecturers so far cover the own travel costs from their travel budgets, commercial companies provide instrumentation and contribute financially to lower the local expenses of the course participants and lecturers. An interesting option for the inclusion of qualified students or technicians to operate the instrumentation or teach methodology at such courses may exist e.g. during a holiday trip to Eastern Europe. ISAC could issue certificates to individuals proposing themselves for such missions. Such certificates seem helpful for further professional life as proof of personal initiative and devotion to tasks of public interest. 6. to *provide* laptop and notebook computers which are too slow to support e.g. time intensive computations e.g. under Windows95 but still very useful for Internet access, data display, document editing, table calculation, database operations and as network servers. It should be self evident that only correctly functioning computers from e.g. 80486/487 processors upward should be considered for such purposes. While the transport of the usual tower computers with their heavy monitors is excluded for weight and space reasons, laptop and notebook computers would be welcome as one piece equipement of small size. The same is true for telephone modems or TCP/IP PCMCIA or parallel interface plugin cards for network access. The property transfer could be organized e.g. via publically registered organisations like ISAC or DGZ into the property of Eastern European institutions. While export regulations would in all likelihood not be against such transfers, it will be important to clarify custom regulations before anything practical is undertaken in this sense. It seems evident from the above that substantial help can be given without need for high a priori financing. Nevertheless we should not forget financial aspects. In remembering Spizek's earlier effort to collect money for such purposes, we should ask for industrial sponsoring of Spizek's ISAC account. As members of cytometric societies we should furthermore urge the officiers in the various national cytometric societies to establish *partnerships* with individual Eastern European countries. This would permit coorganisation of courses or meetings, personal invitations, mailing of CDs or transport of PCs by the various societies in a forseeable and not too costly manner. Such contacts will also establish the urgently needed interpersonal relations, required for long term planning of joint research proposals e.g. within EU programs. The Soros foundation for Eastern Europe may be approachable in addition, and EU coordination program funds devoted to scientific contacts with Eastern Europe may prove useful. Such action will, however, require longer time periods for setup and visible signs of our efforts in the first place. *** Conclusion: Without being exhaustive, I believe that a multitude of immediate and efficient actions can be taken by motivated scientists in this matter without a priori need for a substantial financial assistance. Best regards G.Valet ****************************************************************** Prof.Dr.Guenter K.Valet Max-Planck-Institut fuer Biochemie Cell Biochemistry Am Klopferspitz 18a D-82152 Martinsried Germany Tel: +49/89/8578-2518, -2525, Fax: +49/89/8578-2563 E-mail: valet@vms.biochem.mpg.de Internet: http://www.biochem.mpg.de/valet/cellbio.html ****************************************************************** J.Paul Robinson, Purdue University Cytometry Labs Professor of Immunopharmacology robinson@flowcyt.cyto.purdue.edu PH:317-494 6449 FAX:317-494 0517 web http://www.cyto.purdue.edu
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