On Tue, 21 Jan 1997, Anna Porwit-MacDonald wrote: > > > > > We have just seen a case that is suspected of being AML but is > > positive for CD13 only. It is negative for all other markers > > including CD45. This patient has presented with bilateral renal > > masses and a deep iliac mass. A random bone marrow showed a diffuse > > infiltrate of blast cells believed to be myeloid but only CD13 > > positive. Has anyone else seen any AMLs that are only positive for > > CD13? > > > > Thanks for the help. > > > > Haywood Pyle > > pyle@kfshrc.edu.sa > > > >Hi! > I have not seen such a case in a rather large material > (approx.300 cases studied) ! > Did you check cytoplasmic staining for CD22, CD3, myeloperoxidase? Is CD117 > and CD56 also negative? > CD13 reacts with aminopeptidase-N (ref. among others Favaloro et al, > Leukocyte typing V,p.1788, Oxford University Press 1995), so it is not > impossible that non-hematopoietic tumors may react. Is it possible to > perform cytochemistry (eg chloracetate esterase) on cytologic material? > Would be grateful to know the facit when you have it! > Best wishes > Anna Porwit-MacDonadl > Haematopathology Lab., Department of Pathology, > Karolinska Hopital, Stockholm > > > > I agree with Anna and her questions. I have not seen a case like this in about 1,000 cases of AML studied. Regards, Elisabeth Paietta
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