Re: VALUES FOR %S IN CANCER TISSUE

Bruce Davis, MD - Clinical Pathology (bdavis@beaumont.edu)
Mon, 19 Jun 1995 11:08:31 -0400 (EDT)

What our laboratory does is follow the concensus conference
recommendations and use our local experience to establish separate ranges
for high, intermediate, and low %S (1/3, 1/3, 1/3) cutoffs of aneuploid
and diploid tumors separately. This is admittedly an arbutrary approach
and requires analyzing >100 tumors for each ploidy group, is better than
doing nothing. I share your belief that to clinically report breast tumor
analysis without references ranges is next to worthless or at least
clearly poor laboratory practice.

I like your idea of collating the responses you get; it would be interesting.

Bruce H. Davis, M.D.
Dept. of Clinical Pathology
Wm Beaumont Hospital
Royal Oak, MI 48073

On Fri, 16 Jun 1995 tkute@isnet.is.wfu.edu wrote:

> I am interested in knowing the range of values reported out for %S activity
> when solid tumors such as breast are analyzed. Secondly, I am interested
> in know what most labs do about determining what is a high value versus a
> low value. Since diploid tumors always have lower values than aneuploid
> tumors, do most labs define different cut points for these two groups? If
> they do, how many cut points are used and what are the values for these cut
> points. Are laboratories following the CONSENSUS REPORT OF 1993?
>
> I will be happy to collect the responses and give a summary after a period
> of time. I firmly believe that giving a number without a comment as to its
> relative value of %S is meaningless
> ******************************************************************************
> Dr. Timothy Kute
> Pathology Department TEL# 910-716-2950
> Bowman Gray School of Med. FAX# 910-716-7595
> Medical Center Blvd.
> Winston-Salem, NC 27157-1072 E-MAIL: tkute@isnet.is.wfu.edu
> 910-716-2950 Fax 910-716-7595
>
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