The three figures on the cover illustrate the laboratory and epidemiologic considerations addressed in this volume. The top figure is taken from Chapter 2, Figure 6, Case 11. It shows one of the abnormal B-cell lymphocyte phenotypes, uncovered in the environmental health studies described in Chapter 1, that led to convening the USPHS conference on which this volume is based. The middle figure is taken from Chapter 3, Figure 1. It shows representative selections of lymphocytes from three study participants who were confirmed to have monoclonal B-cell lymphocytosis, a condition associated with malignant diseases including chronic lymphocytic leukemia (CLL) and non-Hodgkin's lymphoma (NHL). The bottom figure is a graph showing the age-adjusted incidence of CLL (lowest curve) and NHL (next-lowest curve) from US cancer surveillance data. Also shown on the graph are data points representing the abnormal B-cell phenotypes described Chapter 1 (shown in red), and data from Chapter 10 on the prevalence of monoclonal B-cell lymphocytosis in the United Kingdom (dashed line). The need to determine the relationship between these laboratory findings, their ultimate expression as disease, and the contribution of environmental risk factors forms the crux of this volume.
 

This publication was supported in whole by funds from the Comprehensive Environmental Response, Compensation, and Liability Act trust fund through the Agency for Toxic Substances and Disease Registry, Public Health Service, U.S. Department of Health and Human Services.
 

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