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1. Having very low RNA content (Proc. Natl. Acad. Sci USA, 73:2881,
1976)- they have approx. 10 fold fewer ribosomes compared to G1 cells
as established in classical studies by Penman and his collaborators
in 60s.
2. Showing minimal uptake of mitochondrial probe Rhodamine 123 (PNAS,
78,2383,1981).
3. Not expressing cyclins D and E (Leukemia, 9: 893, 1995).
There are many other markers discriminating G0 cells, as discussed in
chapters in Flow Cytometry & Sorting, MR Melamed, T Lindmo & ML
Mendelsohn, Eds, Wiley-Liss, 1990
Zbigniew Darzynkiewicz
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web
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CD-ROM Vol 3 was produced by Monica M. Shively and other staff at the
Purdue University Cytometry Laboratories and distributed free of charge
as an educational service to the cytometry community.
If you have any comments please direct them to
Dr. J. Paul Robinson, Professor & Director,
PUCL, Purdue University, West Lafayette, IN 47907.
Phone: (765)-494-0757;
FAX(765) 494-0517;
Web