FLT3

Clone & Isotype	Conjugate	Size	Format			Part Number
SF1.340	Purified	0.2 mg	Freeze-dried		(in dev’t)	IM2036
IgG1 (mouse)

FLT3/FLK2 belongs to the Receptor Tyrosine Kinase (RTK) family of transmembrane glycoproteins which directly binds extracellular ligands and transduces regulatory signals through intracytoplasmic tyrosine kinase activity. Other members of the RTK family are c-kit (CD117), Macrophage Colony-Stimulating Factor Receptor (M-CSFR), and Platelet-Derived Growth Factor Receptor (PDGFR). On normal bone marrow cells, expression of FLT3/FLK2 can be found on fractions of CD34+ as well as CD34- cells. Most of the CD34+++ FLT3/FLK2+ cells co-express c-kit (CD117) at high levels. The SF1.340 antibody is specific for an extracellular domain of FLT3/FLK2. This antibody does not compete with the FLT3 ligand for binding to FLT3.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu