TIA-1

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
TIA-1	Purified	100 tests	Freeze-dried	COULTER CLONE		6604593
IgG1 (mouse)

TIA-1 is a 15 kDa cytoplasmic granule associated protein found in lymphocytes possessing cytolytic potential. Although TIA-1 recognizes a 15 kDa protein in unstimulated T lymphocytes. Activated T lymphocytes are induced to express several higher molecular weight proteins that are also recognized by TIA-1. TIA-1 antigen is expressed in most CD8+ peripheral T lymphocytes and in a minor population of CD4+ peripheral T lymphocytes. It is also expressed in CD4+ and CD8+ activated T cell Clones and in activated natural killer cell Clones. It is not found on B lymphocytes or B cell lines. TIA-1 antibody detects cytolytic effector cells in lymphocytic infiltrates. It is suitable for flow cytometric analysis of permeabilized cells, immunoblotting and immunohistochemistry both on frozen and on paraffin-embedded tissue sections. TIA-1 antibody was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu