Map 4-Antibodies

TCR zeta

TCR-Zeta

Clone & Isotype Conjugate Size Format Line Part Number
TIA-2 Purified 100 tests Freeze-dried COULTER CLONE 6604592
IgG1 (mouse)

The z subunit is a 16 kDa surface molecule associated with the T cell receptor. Its expression is restricted to T lymphocytes and natural killer (NK) cells. In T lymphocytes, the z subunit is expressed as a disulfide-linked homodimer of 32 kDa or as a disulfide-linked heterodimer with a 21 kDa subunit designated h. Both of these dimeric species are non-covalently associated with the remaining subunits of the CD3-TCR-antigen receptor complex. In NK cells, the z subunit is expressed as a disulfide-linked homodimer of 32 kDa or as a disulfide-linked heterodimer with a 12 kDa subunit. It is associated with the CD16 molecule (FcgRIII). TIA-2 antibody recognizes a cytoplasmic epitope of the z subunit of the T lymphocyte receptor complex. It is suitable for immunoprecipitation, immunoblotting, and flow cytometric analysis of permeabilized cells. TIA-2 antibody was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.
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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu