Map 4-Antibodies

P-selectin Glycoprotein-ligand (PSGL-1)

Clone & Isotype Conjugate Size Format Part Number
3E2-25-5 (PL1) Purified 0.2 mg Freeze-dried (in dev’t) IM2090
IgG1 (mouse)
5D8-8-12 (PL2) Purified 0.2 mg Freeze-dried (in dev’t) IM2091
IgG1 (mouse)

PSGL-1 displays specific oligosaccharide sequences which interact with the lectin domain of P-selectin. The epitope on PSGL-1 recognized by the PL1 antibody is in close proximity to this lectin binding site and the antibody completely inhibits the binding of P-selectin to PSGL-1 in a variety of assays. In contrast, the PL2 antibody does not block any binding ofP-selectin to PSGL-1. PL1 and PL2 antibodies react with all leucocytes including circulating dendritic cells, but not with platelets and erythrocytes. Both antibodies can be used in flow cytometry and in immunohistochemistry on frozen and paraffin embedded tissue sections.
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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu