Cytotoxic Effector Cells (C1.7)

Clone & Isotype	Conjugate	Size	Format			Part Number
C1.7	Purified	0.2 mg	Freeze-dried			IM1607
IgG1 (mouse)	PE	100 tests	Liquid	IOTest		IM1608
	PE-Cy5	100 tests	Liquid	IOTest		IM1609

The C1.7 monoclonal antibody recognizes a 38 kDa cell surface signal transduction molecule found on almost all human NK cells. It induces a granule independent killing mechanism by NK effector cells. It is also found on gd TCR T cells and appoximately half of peripheral ab TCR CD8+ T cells. It is not found on B, CD4+ T, or naive CD8+ T cells. Upon activation, most CD8+ T cells become C1.7 positive, however, a small but significant minority of CD8+ T cells remain C1.7 negative. This subset is associated with lower cytotoxic activity, lower g-IFN production and higher IL-4/10 production. C1.7 antibody was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu