CTLA-4

Clone & Isotype	Conjugate	Size	Format			Part Number
BNI3	Purified	0.2 mg	Freeze-dried		(in dev’t)	IM2070
IgG2a (mouse)

CTLA-4 is an integral membrane protein belonging to the immunoglobulin superfamily, which is expressed either as a 30 kDa monomer or as a disulfide-linked homodimer. It is homologous to the T cell antigen CD28, and like CD28, is a ligand for CD80 and CD86. CTLA-4 is transiently expressed by activated T cells, and is not detectable in resting T cells. BNI-3 is useful for the detection of CTLA-4 by flow cytometry, and can also be used in immunohistochemistry on frozen sections. CTLA-4 and CD28 are involved in the costimulation required for T cell activation.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu