CD117

c-kit — Progenitor cells

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
95C3	Purified	100 tests	Liquid	IOTest		IM1359
IgG1 (mouse)	PE	100 tests	Liquid	IOTest		IM1360
	PE-Cy5	100 tests	Liquid	IOTest		IM2043
17F11	Purified	100 tests	Liquid	IOTest		IM1227
IgM (mouse)	Biotin	0.2 mg	Freeze-dried			IM1228

The CD117 antigen is the protooncogene c-kit which belongs to the class III receptor tyrosine kinase family. This antigen is the receptor for a growth factor encoded by the steel locus (Steel Locus Factor "SLF"). The CD117 antigen is expressed on very few normal bone marrow cells. The majority of CD117+ marrow cells co-express CD34. 95C3 and 17F11 antibodies react with BFU-E, CFU-GEMM, CFU-GM and CFU-G. 95C3 antibody reduces the binding of SLF to its receptor to about half of the maximum value. 17F11 antibody down regulates c-kit in a similar fashion to SLF. 95C3 and 17F11 antibodies were evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu