Map 4-Antibodies

CD98

BROAD DISTRIBUTION

Clone & Isotype Conjugate Size Format Line Part Number
JS-5 Purified 100 tests Liquid IOTest IM1606
IgG1 (mouse)

The CD98 antigen is a heterodimer of a glycosylated heavy chain (80 kDa), disulphide-linked with a non-glycosylated light chain (40 kDa). The light chain amino acid sequence and structure are not known, but the heavy chain is a 529 a.a. long, type II integral membrane protein, with four N-linked sites of glycosylation. CD98 antigen is present on T cells and is up-regulated upon activation. It is also expressed at low levels on other cell types including granulocytes, lymphocytes, red blood cells , and at higher levels on monocytes.Activated Natural Killer (NK) cells express high levels of this antigen. JS-5 antibody reacts with the heavy chain of CD98 antigen. It was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.
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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu