CD89

GRANULOCYTES — MONOCYTES

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
A3	Purified	0.2 mg	Freeze-dried			IM1613
IgG1 (mouse)	PE	100 tests	Liquid	IOTest		IM1614

The CD89 antigen (FcaR) is a transmembrane glycoprotein with an extracellular part composed of two Ig superfamily domains.Five sites for N-glycosylation are present. The molecular weight of the molecule is 50-75 kDa.The FcaR is the receptor for soluble IgA1 or IgA2.This antigen is restricted to cells of myelomonocytic lineage. Its expression begins at the promyelocyte differentiation stage.In peripheral blood, A3 antibody is highly reactive with neutrophils, monocytes and eosinophils.CD3+ T cells, CD19+ B cells and CD57+ Natural Killer (NK) cells are negative for A3 antibody labeling.A3 antibody was evaluated during the Fifth International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu