CD63

Activated platelets (GP53)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
CLBGran/12	Purified	100 tests	Liquid	IOTest		IM0768
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM1165
	PE	100 tests	Liquid	IOTest		IM1914

The CD63 antigen is a lysosomal membrane glycoprotein of 53 kDa that is translocated to the plasma membrane after platelet activation. It is also found on monocytes/macrophages and is weakly expressed by resting granulocytes, T cells and B cells. CD63 antigen, present only in azurophilic granules of non-stimulated neutrophils, is strongly expressed on the surface of neutrophils after activation. CD63 is a marker for granule release. This phenomenom is also reported for basophils. CD63 antibodies inhibit adhesion of neutrophils to activated endothelium. CLBGran/12 antibody was evaluated during the Fourth International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu