CD54

ICAM-1

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
84H10	Purified	0.2 mg	Freeze-dried			IM0544
IgG1 (mouse)	Purified	100 tests	Liquid	IOTest		IM0753
	FITC	100 tests	Liquid	IOTest		IM0726
	PE	100 tests	Liquid	IOTest		IM1239

The CD54 antigen is an integral membrane glycoprotein with seven potential N-linked glycosylation sites. It has a 90 kDa molecular weight and is known as the InterCellular Adhesion Molecule-1 (ICAM-1). It mediates the adhesion of T cells with Antigen-Presenting Cells (APC) and is involved in T cell to T cell and T cell to B cell interactions. It is also involved in the adhesion of monocytes, lymphocytes and neutrophils to activated endothelium. It binds to the integrins LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18), to rhinovirus, and to CD43. It is expressed by endothelial cells and by many cell types upon activation. 84H10 antibody inhibits ICAM-1 mediated adhesion to LFA-1. 84H10 antibody was evaluated during the Third International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu