CD49d

VLA-a4 CHAIN

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
HP2/1	Purified	0.2 mg	Freeze-dried			IM0764
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM1404

The CD49d antigen is the 150 kDa integrin a4 chain which is non-covalently associated with the 130 kDa integrin b1-chain (CD29 molecule) forming the VLA-4 complex. It is the receptor for fibronectin and for VCAM-1. When associated with integrin b7 subunit in mucosal lymphocytes, it is known as the receptor for Mucosal vascular ADdressin (MadCAM-1). It is expressed by monocytes, lymphocytes, eosinophils, thymocytes and Langerhans cells. HP2/1 antibody blocks the interaction of VLA-4 with VCAM-1. This antibody was evaluated during the Fourth International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu