Map 4-Antibodies

CD49c

VLA-a3 CHAIN

Clone & Isotype Conjugate Size Format Part Number
C3VLA3 Purified 0.2 mg Freeze-dried IM2000
IgG1 (mouse)

The CD49c antigen is the 150 kDa integrin a3 chain which is non-covalently associated with the 130 kDa integrin b1-chain (CD29 molecule) forming the VLA-3 complex (a3b1 or CD49c/CD29). It is known as the laminin, collagen, fibronectin, invasin and epiligrin receptor. C3VLA3 antibody recognizes an amino-terminal epitope of the integrin a3 chain and immunoprecipitates the 120-130 kDa fragment under reducing conditions. This antibody reacts with several human cells including some peripheral blood lymphocytes and High passage cultured human Umbilical Vein Endothelial Cells (HUVECs). It does not react with monocytes and granulocytes. It also reacts with smooth muscle cells of some blood vessels in normal human breast, kidney and liver and basal cells of the epidermis. It does not react with skeletal and cardiac muscle cells. C3VLA3 antibody is a blocking antibody. It is also suitable for immunohistochemistry on frozen tissue sections.
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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu