CD44

Phagocytic glycoprotein-1 (Pgp-1)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
J.173	Purified	0.2 mg	Freeze-dried			IM0845
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM1219

The CD44 family of molecules are transmembraneous proteins with extensive N- and O-linked glycosylation. The standard glycosylated form has a molecular weight of 80-90 kDa. Multiple larger CD44 variant isoforms that arise by alternative splicing of 10 supernumerary genomic exons, have also been described. The CD44 molecules are found on leukocytes (especially on T cells), on red blood cells and weakly on platelets. They are also expressed on bone marrow CD34+ progenitor cells, on brain tissues and epithelial cells. A wide variety of functions have been ascribed to the CD44 molecules including hyaluronate binding, lymphocyte homing to High Endothelial Venules (HEV) and regulation of LFA-3 adhesion. The human blood group antigens Ina/b reside on CD44. J.173 antibody does not inhibit the binding of hyaluronate to its receptor. It can trigger IL-2-dependent proliferation and cytotoxicity of human T cell Clones in vitro. This antibody was evaluated during the Third International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu