CD35

COMPLEMENT RECEPTOR TYPE ONE (CR1)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
J3D3	Purified	0.2 mg	Freeze-dried			IM0195
IgG1 (mouse)	FITC	100 tests	Liquid	IOTest		IM1836

The CD35 antigen exists as four different allotypes with molecular weight s of 160, 190, 220 and 250 kDa. It is known as the Complement Receptor type one (CR1) with affinity to C3b, C4b and iC3b. It is expressed by granulocytes (except basophils), B cells, monocytes, some Natural Killer (NK) cells and erythrocytes. J3D3 inhibits CR1-mediated decay of cells bound to the alternative and classical pathway to C3-convertase sites. It also inhibits C3b dependent rosette formation with lymphocytes. J3D3 antibody was evaluated during the Fourth International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu