CD32

LOW AFFINITY IgG Fc RECEPTOR (FcgRII)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
2E1	Purified	0.2 mg	Freeze-dried			IM0417
IgG2a (mouse)	PE	100 tests	Liquid	IOTest		IM1935

FcgRII proteins exist as six potential isoforms encoded by three genes, designated as A, B, and C. The molecular weight of these isoforms are relatively constant, between 40-43 kDa. FcgRIIA and FcgRIIC are similar but not identical in their extracellular domains and have identical transmembrane and cytoplasmic sequences.FcgRIIB is different for its cytoplasmic sequence.Monocytes carry all forms of FcgRII, neutrophils carry FcgRIIA and C but B lymphocytes only express FcgRIIB forms. 2E1 antibody recognizes all the antigen isoforms. It was evaluated during the Third International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu