CD25

IL-2 RECEPTOR

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
1HT44H3 (IL-2R1)	Purified	100 tests	Freeze-dried	COULTER CLONE		6603092
IgG2a (mouse)	FITC	100 tests	Freeze-dried	COULTER CLONE		6603200
B1.49.9	Purified	0.2 mg	Freeze-dried			IM0119
Ig2a (mouse)	Biotin	0.2 mg	Freeze-dried			IM0266
	Purified	100 tests	Liquid	IOTest		IM0477
	FITC	100 tests	Liquid	IOTest		IM0478
	PE	100 tests	Liquid	IOTest		IM0479
	PE-Cy5	100 tests	Liquid	IOTest		IM2044
33B3.1	Purified	0.2 mg	Freeze-dried			IM0317
IgG2a (rat)	FITC	100 tests	Liquid	IOTest		IM0481
CYTO-STATS

The CD25 (IL-2R1) antigen is a single-chain glycoprotein with a molecular weight of 55 kDa which is the low affinity receptor for IL-2 (IL-2Ra). In conjunction with p75 (CD122 antigen; IL-2Rb), CD25 antigen forms a high-affinity IL-2R complex. It is found on activated T and B cells, on activated macrophages and on T cell Clones. It is also expressed on Natural Killer (NK) cells enriched from peripheral blood lymphocytes by culturing in the presence of IL-2. It is absent from thymocytes and resting T and B cells. B1.49.9 antibody does not block the binding of IL-2 to its receptor. 33B3.1 antibody inhibits IL-2-driven cell proliferation. IL-2R1 and 33B3.1 antibodies were evaluated during the Second International Workshop on Human Leukocyte Differentiation Antigens. B1.49.9 antibody was evaluated during the Third Workshop.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu