Map 4-Antibodies

CD11b

MAC-1 INTEGRIN aM-CHAIN

Clone & Isotype Conjugate Size Format Line Part Number

94 (Mo1) Purified 100 tests Freeze-dried COULTER CLONE 6602147
IgM (mouse) FITC 100 tests Freeze-dried COULTER CLONE 6602573

Bear1 Purified 0.2 mg Freeze-dried IM0190
IgG1 (mouse) Purified 100 tests Liquid IOTest IM0474
FITC 100 tests Liquid IOTest IM0530


The CD11b antigen (Mac1) is the 165 kDa integrin aM-chain, non-covalently associated with the 95 kDa CD18 antigen (integrin b2). It has been identified as the C3bi Complement Receptor (CR3). As a member of the b2 integrin family of adhesion molecules, Mac-1 mediates polymorphonuclear and monocyte adherence to endothelium. The CD11b ligands are ICAM-1 (CD54), factor X, fibrinogen and endotoxin. CD11b antibodies react with myeloid and Natural Killer (NK) cells in the peripheral blood. They recognize peripheral blood lymphocytes and a subset of T cells. A portion of CD11b+ cells is also positive for CD8. They react also with granulocytes and monocytes. Bear1 is not a blocking antibody. Mo1 antibody was evaluated during the First International Workshop on Human Leukocyte Differentiation Antigens. Bear1 antibody was evaluated during the Fifth Workshop.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu