Map 4-Antibodies

CD11a

LFA-1 INTEGRIN aL-CHAIN

Clone & Isotype Conjugate Size Format Line Part Number
25.3 Purified 0.2 mg Freeze-dried IM0157
IgG1 (mouse) FITC 100 tests Liquid IOTest IM0860
PE 100 tests liquid IOTest IM1433

The CD11a antigen, Leukocyte Function Associated molecule-1 (LFA-1), is the 180 kDa integrin aL-chain, non-covalently associated with the 95 kDa CD18 antigen (integrin b2). It promotes homotypic adhesion between lymphoid cells and heterotypic adhesion of lymphoid cells to the vascular endothelium. LFA-1 can interact with different ligands; the InterCellular Adhesion Molecules (ICAM): ICAM-1 (CD54), ICAM-2 (CD102) and ICAM-3 (CD50). CD11a antibodies react strongly with all leukocytes but do not recognize platelets. They react with peripheral blood T and B cells and with a portion of monocytes and granulocytes. They also stain thymocytes presents in bone marrow. 25.3 is a blocking antibody. It was evaluated during the Third International Workshop on Human Leukocyte Differentiation Antigens.
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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu