CD10

COMMON ACUTE LYMPHOCYTIC LEUKEMIA ANTIGEN (CALLA)

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
J5	FITC	50 tests	Liquid	CYTO-STAT		6604107
IgG2a (mouse)	RD1	50 tests	Liquid	CYTO-STAT		6604120
Other mAbs

The CD10 antigen is refered to as the Common Acute Lymphoblastic Leukemia Antigen (CALLA). It is a type II integral membrane protein, identified as the human membrane-associated neutral endopeptidase, with a molecular weight of 100 kDa. It is expressed on uncommitted lymphoid precursors. CD10 expression is lost as cells enter the T lineage. In the B lineage, CD10 expression is lost later, as cells acquire surface Ig expression. It is also expressed on activated and proliferating B cells in the germinal center and on neutrophils. J5 antibody was characterized during the First International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu