CD4

HELPER T CELLS

Clone & Isotype	Conjugate	Size	Format	Line		Part Number
SFCI12T4D11 (T4)	FITC	50 tests	Liquid	CYTO-STAT	IVD	6603862
IgG1 (mouse)	RD1	50 tests	Liquid	CYTO-STAT	IVD	6603850
	ECD	50 tests	Liquid	CYTO-STAT		6604727
Other mAbs

The CD4 (T4) antigen is a single-chain transmembrane glycoprotein with a 59 kDa molecular weight. It is found on a specific subset of peripheral T lymphocytes, the so-called "helper" cells. It is present on most thymocytes where it is frequently co-expressed with CD8. CD4 is also expressed on monocytes at a lower density than on CD4+ T cells. CD4+ T cell subset is active in inducing and helping the synthesis of immunoglobulins by B cells. CD4 is an accessory molecule for the MHC class II molecule recognition by helper T cells.CD4 is a receptor for the Human Immunodeficiency Virus (HIV). T4 antibody antagonizes HIV effects in vitro. T4 antibody was characterized during the First International Workshop on Human Leukocyte Differentiation Antigens.

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CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu