Summary

Summary

• Primary hypothesis of target concentration strategies
• Why we use plasma/serum for sampling
• Drug concentration (C) vs Time (t) plots -- proper graphing
• Minimum Effective Concentration (MEC)
• Minimum Toxic Concentration (MTC)
  (added concept of "need" to have low trough in some cases)
• Therapeutic Window; Target Concentration Range
  (related concept of "Therapeutic Index")
• Dosage adjustment -- simple cases --> Simple proportion
• Assumptions for "simple" dose adjustment
  • Dose interval (T) stays same
  • No significant change in animal's handling of the drug
  • Kinetic processes not dose dependent
• Need to pay attention to whether it is peak or trough that you are adjusting!
• Importance of need for knowing "peak" and "trough" concentrations depends on the drug
  New concept: OSCILLATION during dosage interval (more later)
• Best times to take samples