Volume of Distribution
and Loading Dose

Calculating an Initial Dose

Amount of Drug = Desired Conc * Volume

{mg = (mg/L) * L}

Loading Dose

Information needed to calculate a DL

Finding Vd

Earlier formula rearranged!

Vd = Dose / Measured Conc

{L = mg / (mg/L) }

"Vd" is equivalent to "volume"
"dose" is equivalent to "amount of drug"
"measured" is equivalent to "desired"

{Note: in "real" pharmacokinetics, one would use
much more complex analyses to find what is known
as the volume of distribution at steady state (Vd(ss))}

Summarizing statements for Vd

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Last modified: 04 Sep 1996 10:34 glc