Pharmacokinetics Goals

General Goals

• Pharmacokinetics vs pharmacodynamics
• Diagnosis of toxicoses
• Establishing / adjusting dosage regimens
• Understanding withdrawal times for food safety

Detailed Goals

• Understand terms
  • Steady State
  • First- & Zero-order kinetics / Michaelis-Menten plots
  • Loading Dose / Volume of Distribution
  • Clearance
  • Ke (Elimination Rate) & Half-Life
  • Bioavailability
  • Compartment modeling
    • One compartment model
    • Two (and more) compartment models
• Adjust dose
  • Be able to establish new dose regimens:
  • Be able to account for dose forms available
  • Be able to predict, at steady state, the Peak and Trough concentrations
  • Timing of samples
• Withdrawal time -- primarily for veterinary students
  • Be able to describe significance of withdrawal times
  • Be able to predict theoretical withdrawal time given key parameters
  • Be able to describe effects of changes in dose regimen on withdrawal time