- Think about safety margins
Example: penicillin G versus gentamicin
- Think of ease of "bioassaying" the drug in the
patient, i.e., presence of easily detectable and rapid
response
Example: anticonvulsant versus anesthetic agent
- What if signs of too little and too much drug are
similar?
Example: digoxin
- When interindividual variation is much greater
in
DOSE vs PLASMA CONCENTRATION than in
PLASMA CONCENTRATION vs EFFECT!
Send suggestions /
questions
Last modified: 02 Sep 1996 19:29 glc