INTRODUCTION TO ANTIMICROBIAL DRUGS

Copyright: Purdue Research Foundation, 1996

| BMS 445 Intro | | Drug Groups | | E-mail | | Full Text | | Slides/Graphics |


Main Topics


Historical Perspective
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Definitions
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Sources of antimicrobials
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Classification Schemes
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Chemical classifications
| classification schemes | | main topics | | top | | e-mail |

[ Drug Listings ]

Mechanism of Action
| classification schemes | | main topics | | top | | e-mail |

Antibacterial Activity
| classification schemes | | main topics | | top | | e-mail |

Definition of resistance / sensitivity
antibacterial activity | classification schemes | | main topics | | top | | e-mail |

Predicted Spectrum
antibacterial activity | classification schemes | | main topics | | top | | e-mail |

Cidal versus Static
antibacterial activity | classification schemes | | main topics | | top | | e-mail |

Predictability of sensitivity / resistance
antibacterial activity | classification schemes | | main topics | | top | | e-mail |

Predictable: Fairly unpredictable -- Senstivity tests advised

Categories of resistance
| antibacterial activity | | classification schemes | | main topics | | top | | e-mail |

Antimicrobials may be ineffective against bacteria because of resistance that is

Natural resistance
| antibacterial activity | | categories of resistance | | e-mail |
Mutational / Secondary resistance
| antibacterial activity | | categories of resistance | | e-mail |

Induced resistance
| antibacterial activity | | categories of resistance | | e-mail |
Transferrable resistance
| antibacterial activity | | categories of resistance | | e-mail |
Conjugation
| transferrable resistance | | categories of resistance | | antibacterial activity | | e-mail |
Bacteriophage transmission
Transposons

Biochemical Mechanisms of Resistance
antibacterial activity | classification schemes | | main topics | | top | | e-mail |

Basic biochemical mechanisms of resistance include:

INACTIVATION OF DRUG:
| biochemical mechanisms of resistance |
DECREASED ACCUMULATION:
| biochemical mechanisms of resistance |
DECREASED AFFINITY / BINDING:
| biochemical mechanisms of resistance |
METABOLIC BY-PASS
| biochemical mechanisms of resistance |


Adverse Effects
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Adverse effects of antimicrobials may be divided into three broad categories:

Allergic Reactions to Antimicrobials
| adverse effects | | top | | main topics | | e-mail |

Biological Adverse Effects of Antimicrobials
| adverse effects | | top | | main topics | | e-mail |

Toxic Effects of Antibacterials
| adverse effects | | top | | main topics | | e-mail |


References
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