ANTIFUNGAL AGENTS
Outline

Copyright, Purdue Research Foundation, 1996

| BMS 445 Intro | | Drug Groups | | Slides / Graphics | | Address | | E-mail | | Full |


NOTE: "**" = Note in notes in BIRC 4/19/96

Overview

Drugs

ANTIFUNGAL DRUGS
DrugInfection TypeRoute/SiteMechanismChemical Group
Amphotericin BDeep/DermIV for Systemic/TopicalCell membranePolyene
NystatinDerm/YeastPO for GI/Topical/VaginalCell membranePolyene
ItraconazoleDeepPO for SystemicCell membraneAzole
FluconazoleDeepIV,PO for SystemicCell membraneAzole
KetoconazoleDeep/DermPO for Systemic/TopicalCell membraneAzole
MiconazoleDeep/DermIV for Systemic/TopicalCell membraneAzole
SulconazoleDermTopicalCell membraneAzole
ClotrimazoleDerm/YeastTopical/VaginalCell MembraneAzole
EnilconazoleDermTopicalCell MembraneAzole
EconazoleDerm/YeastTopical/VaginalCell membraneAzole
OxiconazoleDerm/YeastTopical/VaginalCell membraneAzole
TioconazoleDerm/YeastTopical/VaginalCell membraneAzole
TerconazoleYeastVaginalCell membraneAzole
ButoconazoleYeastVaginalCell membraneAzole
ThiabendazoleDermTopicalCell membraneAzole
FlucytosineDeepPO for SystemicNuclearPyrimidine
GriseofulvinDermPO for TopicalNuclearOther
CiclopiroxDermTopical----
HaloproginDermTopicalUnknown--
NaftifineDermTopicalCell membraneAllylamine
TerbinafineDermTopicalCell membraneAllylamine
Natamycin1Derm/YeastsOphthalmic Topical?Tetraene
TolnaftateDermTopicalCell membraneThiocarbamate
Undecylenic acidDerm Topical--Weak acid
MafenideDermTopicalFolic acidSulfonamide
DapsoneDeepSystemicFolic acidSulfonamide
Potassium IodideDeepSystemic----
Silver SulfadiazineDermTopical----
Gentian VioletYeastVaginal----
Carbol-FuchsinDermTopical----
Cilofungin
(experimental)
----Cell WallOther
----------
Route data based on USPDI'95
MOA in part based on Heit&Riviere'95, USPDI'96
1Only FDA approved product for topical ophthalmic use in humans (Moore'95)

Pathogens / typical drugs

Key differences -- Pathogens / host

Basis for some selectivity

Amphotericin B (FungizoneR)

Structure and chemical characteristics

Mechanism of action

Pharmacokinetics

Adverse Effects

Azole Derivatives

Overview

Mechanism of Action

Ketoconazole (NizoralR)

Pharmacokinetics

Adverse effects

Miconazole (MonistatR, ConofiteR)

Pharmacokinetics

Adverse effects

Itraconazole (SporanoxR

Pharmacokinetics

Adverse effects

Clinical uses

Fluconazole (DiflucanR)

Pharmacokinetics

Adverse effects

Clinical uses

Clotrimazole

(LotriminR, Gyne-LotriminR, MycelexR, Mycelex-GR)

Mechanism of action

Pharmacokinetics

Adverse effects

Uses

Griseofulvin (FulvicinR)

Application

Structure and chemistry

Mechanism of Action

Pharmacokinetics

Adverse Effects

Terbinafine

Adverse effects

Tolnaftate (TinactinR and others, OTC)

Whitfield's ointment

Potassium Iodide

Adverse effects

Others

See Heit & Riviere'95

References


| Drug Groups | | top |
Gordon L. Coppoc, DVM, PhD
Professor of Veterinary Pharmacology
Head, Department of Basic Medical Sciences
School of Veterinary Medicine
Purdue University
West Lafayette, IN 47907-1246
Tel: 317-494-8633Fax: 317-494-0781
Email: coppoc@vet.purdue.edu

Last modified 9:56 AM on 4/19/96 GLC