Cell Biochemistry Martinsried

Melanoma Survival Assessment
from Clinical Parameters

G.Valet, F.Otto1)

1) Fachklinik-Hornheide d.Univ., Münster, Germany

Malignant melanomas are usually surgically removed upon histological confirmation of the diagnosis from bioptic material. This intervention either cures the malignant affection or the disease further progresses. There is a high need at this point to establish individual patient prognosis to rationally decide e.g. on chemotherapy after surgery.

It was investigated whether several routinely determined clinical parameters like: diameter, infiltration depth, presence of an ulcerative surface and localisation of the tumor in conjunction with flow cytometric DNA-aneuploidy and determination of S-phase cells contained prognostic information at the individual patient level. Deeply infiltrated, large and ulcerated tumors are statistically accepted signs for bad patient prognosis, the predictive value of any one of the parameters alone is not sufficient to reliably foresee the ultimate disease outcome for individual patients.

Data were classified in a standardized and automated way with the CLASSIF1 (2) multiparameter data analysis program (Ann.NY Acad.Sci.677,233-251(1993)).

It was found that the resulting triple matrix pattern classifier permits to predict disease outcome substantially better than any single one of the three most discriminative parameters: tumor diameter, infiltration depth and ulceration.

The provided database contains data from 300 surviving (>10 years) and dead patients can be On-line classified to demonstration the comparatively short learning time of the CLASSIF1 self learning algorithm.

For problems or comments, please contact:
G.Valet, E-mail: valet@vms.biochem.mpg.de, Max-Planck-Institut für Biochemie, Am Klopferspitz 18a, D-82152 Martinsried, Germany, Tel: +49/89/8578-2518, -2525, Fax: +49/89/8578-2563, INTERNET address: http://www.biochem.mpg.de/valet/cellbio.htmll
Last Update: Oct.15, 1996

Home Page Table of Contents Sponsors Web Sites
CD ROM Vol 2 was produced by staff at the Purdue University Cytometry Laboratories and distributed free of charge as an educational service to the cytometry community. If you have any comments please direct them to Dr. J. Paul Robinson, Professor & Director, PUCL, Purdue University, West Lafayette, IN 47907. Phone:(317) 494-0757; FAX (317) 494-0517; Web http://www.cyto.purdue.edu EMAIL robinson@flowcyt.cyto.purdue.edu